30 June 2006

Henry Ford’s idea revisited in DNA copying

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Researchers at the University of Dundee have made a significant new discovery about how cells copy their genetic information accurately and efficiently to avoid cancers and other diseases, as reported in the scientific journal Cell, published on 30th June.

Dr Tomo Tanaka, Professor Julian Blow and their team member Dr Etsushi Kitamura at the University’s School of Life Sciences, discovered that, contrary to conventional views, the machinery that copies DNA stays fixed inside the cell whilst the DNA being copied has to move.

DNA is a string-like material found in our cells, which encodes all our genetic information. For the genetic information to be properly inherited, a cell must copy its DNA using a specialized copying machine before it can divide into two daughter cells. It was originally thought that the DNA copying machine moves along the DNA as it is copied.

Dr Tomo Tanaka says "We can liken the process that we have discovered in cells to an assembly line for making cars, invented by Henry Ford and his engineers. It was a revolutionary idea in industry that products move along a line and engineers stay at fixed places to assemble them. This achieved much more accuracy and efficiency in manufacturing products."

"Similarly cells can copy DNA accurately and efficiently by moving it through a stationary copying machine, rather than by moving the copying machinery along stationary DNA. Because errors in DNA copying cause human diseases such as cancers, it is crucial to understand how our cells organize the copying of DNA in space and time".

Dr Tomo Tanaka and Professor Julian Blow are Principal Investigators in the Division of Gene Regulation and Expression in School of Life Sciences at the University of Dundee.

Professor Angus Lamond, Head of the Division of Gene Regulation and Expression said "Cancer is a disease caused by cells dividing and multiplying out of control. This latest advance is a wonderful example of how genetic research in Dundee is leading the way in understanding how cells divide and therefore helps us understand the basic causes of cancer. Future cancer treatments will build upon this improved understanding of what has gone wrong."

The study, entitled "Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories" is published by Cell on 30 June. The research is funded by Cancer Research UK.

For further information please contact Dr Tanaka via E-mail t.tanaka@lifesci.dundee.ac.uk or TEL 01382 385814.

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